P53 Is a Host Cell Regulator during Herpes Simplex Encephalitis.

ABSTRACT:

Unlabelled

p53 is a critical host cell factor in the cellular response to a broad range of stress factors. We recently reported that p53 is required for efficient herpes simplex virus 1 (HSV-1) replication in cell culture. However, a defined role for p53 in HSV-1 replication and pathogenesis in vivo remains elusive. In this study, we examined the effects of p53 on HSV-1 infection in vivo using p53-deficient mice. Following intracranial inoculation, p53 knockout reduced viral replication in the brains of mice and led to significantly reduced rates of mortality due to herpes simplex encephalitis. These results suggest that p53 is an important host cell regulator of HSV-1 replication and pathogenesis in the central nervous system (CNS).

Importance

HSV-1 causes sporadic cases of

SUBMITTER: Maruzuru Y 

PROVIDER: S-EPMC4944289 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature