A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals.

ABSTRACT:

Background

The issue of endocrine disrupting chemicals (EDCs) is receiving wide attention from both the scientific and regulatory communities. Recent analyses of the EDC literature have been criticized for failing to use transparent and objective approaches to draw conclusions about the strength of evidence linking EDC exposures to adverse health or environmental outcomes. Systematic review methodologies are ideal for addressing this issue as they provide transparent and consistent approaches to study selection and evaluation. Objective methods are needed for integrating the multiple streams of evidence (epidemiology, wildlife, laboratory animal, in vitro, and in silico data) that are relevant in assessing EDCs.

Methods

We have developed a framework for the systematic review

SUBMITTER: Vandenberg LN 

PROVIDER: S-EPMC4944316 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature