Airway Surfactant Protein D Deficiency in Adults With Severe Asthma.

ABSTRACT:

Background

Surfactant protein D (SP-D) is an essential component of the innate immune defense against pathogens within the airways. SP-D also regulates allergic inflammation and promotes the removal of apoptotic cells. SP-D dysregulation is evident in several pulmonary diseases. Our aim was to investigate whether airway and serum levels of SP-D are altered in treatment-resistant severe asthma.

Methods

SP-D concentrations were measured in matched serum and BAL samples collected from 10 healthy control subjects (HC) and 50 patients with asthma (22 with mild asthma [MA] and 28 with severe asthma [SA]). These samples were also evaluated by using Western blot analysis to investigate variations in SP-D size.

Results

SP-D levels in BAL samples were significantly lower in SA

SUBMITTER: Mackay RM 

PROVIDER: S-EPMC4944769 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature