Effect of Age on Phenotype and Outcomes in Pulmonary Arterial Hypertension Trials.

ABSTRACT:

Background

In recent years, the population of patients with pulmonary arterial hypertension (PAH) has changed dramatically, including more advanced age at diagnosis. We hypothesized that older patients have a distinct clinical profile with different disease characteristics and response to intervention.

Methods

All previously published treatment studies for PAH conducted by United Therapeutics including seven randomized, placebo-controlled trials and one extension study were included and analyzed to assess the association of age with various demographic, functional, hemodynamic, and outcome variables.

Results

A total of 2,627 patients across three age groups were included: ≤ 50 (n = 1,438, 54.7%), 51 to 64 (n = 780, 29.7%), and ≥ 65 years (n = 409, 15.6%). In compariso

SUBMITTER: Rose JA 

PROVIDER: S-EPMC4944788 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature