FOXL2 Is an Essential Activator of SF-1-Induced Transcriptional Regulation of Anti-Mullerian Hormone in Human Granulosa Cells.

ABSTRACT: Anti-Müllerian hormone (AMH) is required for proper sexual differentiation by regulating the regression of the Müllerian ducts in males. Recent studies indicate that AMH could be an important factor for maintaining the ovarian reserve. However, the mechanisms of AMH regulation in the ovary are largely unknown. Here, we provide evidence that AMH is an ovarian target gene of steroidogenic factor-1 (SF-1), an orphan nuclear receptor required for proper follicle development. FOXL2 is an evolutionally conserved transcription factor, and its mutations cause blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES), wherein affected females display eyelid defects and premature ovarian failure (POF). Notably, we found that functional FOXL2 is essential for SF-1-induced AMH regulation, via

SUBMITTER: Jin H 

PROVIDER: S-EPMC4944948 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature