Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability.

ABSTRACT: Dengue is the most prevalent arboviral disease in humans and a major public health problem worldwide. Systemic plasma leakage, leading to hypovolemic shock and potentially fatal complications, is a critical determinant of dengue severity. Recently, we and others described a novel pathogenic effect of secreted dengue virus (DENV) non-structural protein 1 (NS1) in triggering hyperpermeability of human endothelial cells in vitro and systemic vascular leakage in vivo. NS1 was shown to activate toll-like receptor 4 signaling in primary human myeloid cells, leading to secretion of pro-inflammatory cytokines and vascular leakage. However, distinct endothelial cell-intrinsic mechanisms of NS1-induced hyperpermeability remained to be defined. The endothelial glycocalyx layer (EGL) is a network of m

SUBMITTER: Puerta-Guardo H 

PROVIDER: S-EPMC4944995 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature