Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy.

ABSTRACT: The clinical course of IgA nephropathy (IgAN) and its outcome are extremely variable. Proteinuria at baseline has been considered one of the most important risk factors. More recently, mean proteinuria of follow-up (time-average proteinuria: TAp) was described as a stronger marker of renal survival, suggesting to consider it as a marker of disease activity and response to treatment. We evaluated predictors of renal survival in IgAN patients with different degrees of renal dysfunction and histological lesions, focusing on the role of the therapy in influencing TAp. We performed a retrospective analysis of three prospective, randomized, clinical trials enrolling 325 IgAN patients from 1989 to 2005. Patients were divided into 5 categories according to TAp. The primary endpoint of the 100% inc

SUBMITTER: Sarcina C 

PROVIDER: S-EPMC4945016 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature