Circulating Extracellular RNA Markers of Liver Regeneration.

ABSTRACT:

Background and aims

Although a key determinant of hepatic recovery after injury is active liver regeneration, the ability to detect ongoing regeneration is lacking. The restoration of liver mass after hepatectomy involves systemic changes with coordinated changes in gene expression guiding regenerative responses, activation of progenitor cells, and proliferation of quiescent hepatocytes. We postulated that these responses involve intercellular communication involving extracellular RNA and that these could represent biomarkers of active regenerative responses.

Methods

RNA sequencing was performed to identify temporal changes in serum extracellular non-coding RNA after partial hepatectomy in C57BL/6 male mice. Tissue expression of selected RNA was performed by microarray analy

SUBMITTER: Yan IK 

PROVIDER: S-EPMC4945050 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature