Deficits in context-dependent adaptive coding of reward in schizophrenia.

ABSTRACT: Theoretical principles of information processing and empirical findings suggest that to efficiently represent all possible rewards in the natural environment, reward-sensitive neurons have to adapt their coding range dynamically to the current reward context. Adaptation ensures that the reward system is most sensitive for the most likely rewards, enabling the system to efficiently represent a potentially infinite range of reward information. A deficit in neural adaptation would prevent precise representation of rewards and could have detrimental effects for an organism's ability to optimally engage with its environment. In schizophrenia, reward processing is known to be impaired and has been linked to different symptom dimensions. However, despite the fundamental significance of coding rew

SUBMITTER: Kirschner M 

PROVIDER: S-EPMC4945098 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature