CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.

ABSTRACT: The mechanisms by which exercise mediates its multiple cardiac benefits are only partly understood. Prior comprehensive analyses of the cardiac transcriptional components and microRNAs dynamically regulated by exercise suggest that the CBP/p300-interacting protein CITED4 is a downstream effector in both networks. While CITED4 has documented functional consequences in neonatal cardiomyocytes in vitro, nothing is known about its effects in the adult heart. To investigate the impact of cardiac CITED4 expression in adult animals, we generated transgenic mice with regulated, cardiomyocyte-specific CITED4 expression. Cardiac CITED4 expression in adult mice was sufficient to induce an increase in heart weight and cardiomyocyte size with normal systolic function, similar to the effects of enduranc

SUBMITTER: Bezzerides VJ 

PROVIDER: S-EPMC4945110 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature