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Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.

ABSTRACT: High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.

SUBMITTER: Pulavarti SV

PROVIDER: S-EPMC4945113 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.

Pulavarti Surya V S R K SV Huang Yuanpeng J YJ Pederson Kari K Acton Thomas B TB Xiao Rong R Everett John K JK Prestegard James H JH Montelione Gaetano T GT Szyperski Thomas T

Journal of structural and functional genomics 20140703 4

High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions. ...[more]

PMID: 24989974

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