Moderate Alcohol Use and Insulin Action in Chronic Hepatitis C Infection.

ABSTRACT:

Background and aim

Chronic hepatitis C (HCV) is associated with metabolic abnormalities including insulin resistance (IR) and diabetes. While moderate alcohol consumption is known to have beneficial metabolic effects in the general population, such potential effects in HCV are unknown. We aimed to assess the association between graded alcohol intake and IR, insulin secretion, and metabolic syndrome in HCV.

Methods

Ninety-five non-diabetic HCV-infected patients underwent detailed metabolic testing. IR was directly measured via steady-state plasma glucose (SSPG) during a 240-min insulin suppression test. Total insulin secretion and insulinogenic index were determined by 75-g oral glucose tolerance test. Genotyping of CYP2E1 was performed to detect genetic polymorphisms influen

SUBMITTER: Burman BE 

PROVIDER: S-EPMC4945365 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature