Statistical analysis of structural determinants for protein-DNA-binding specificity.

ABSTRACT: DNA-binding proteins play critical roles in biological processes including gene expression, DNA packaging and DNA repair. They bind to DNA target sequences with different degrees of binding specificity, ranging from highly specific (HS) to nonspecific (NS). Alterations of DNA-binding specificity, due to either genetic variation or somatic mutations, can lead to various diseases. In this study, a comparative analysis of protein-DNA complex structures was carried out to investigate the structural features that contribute to binding specificity. Protein-DNA complexes were grouped into three general classes based on degrees of binding specificity: HS, multispecific (MS), and NS. Our results show a clear trend of structural features among the three classes, including amino acid binding propensi

SUBMITTER: Corona RI 

PROVIDER: S-EPMC4945413 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature