Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.

ABSTRACT: We previously found that aspirin decreases the risk of cerebral aneurysm rupture in humans. We aim to assess whether a sex differential exists in the response of human cerebral aneurysms to aspirin and confirm these observations in a mouse model of cerebral aneurysm. A nested case-control analysis from the International Study of Unruptured Intracranial Aneurysms was performed to assess whether a sex differential exists in the response of human cerebral aneurysms to aspirin. A series of experiments were subsequently performed in a mouse model of cerebral aneurysms. Aneurysms were induced with hypertension and elastase injection into mice basal cisterns. We found that aspirin decreased the risk of aneurysm rupture more significantly in men than in women in the International Study of Unruptur

SUBMITTER: Chalouhi N 

PROVIDER: S-EPMC4945417 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature