Ontology highlight
ABSTRACT:
SUBMITTER: Allemann O
PROVIDER: S-EPMC4945418 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160701 27
Many natural products, including vinblastine, have not been easily subjected to simplifications in their structures by synthetic means or modifications by late-stage semisynthetic derivatization in ways that enhance their biological potency. Herein, we detail a synthetic vinblastine that incorporates added benign complexity (ABC), which improves activity 10-fold, and is now accessible as a result of advances in the total synthesis of the natural product. The compound incorporates designed added ...[more]