Toward a cumulative science of functional integration: A meta-analysis of psychophysiological interactions.

ABSTRACT: Much of the work in cognitive neuroscience is shifting from a focus on single brain regions to a focus on the connectivity between multiple brain regions. These inter-regional connectivity patterns contribute to a wide range of behaviors and are studied with models of functional integration. The rapid expansion of the literature on functional integration offers an opportunity to scrutinize the consistency and specificity of one of the most popular approaches for quantifying connectivity: psychophysiological interaction (PPI) analysis. We performed coordinate-based meta-analyses on 284 PPI studies, which allowed us to test (a) whether those studies consistently converge on similar target regions and (b) whether the identified target regions are specific to the chosen seed region and psychol

SUBMITTER: Smith DV 

PROVIDER: S-EPMC4945436 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature