Genetic predictors of relapse rate in pediatric MS.

ABSTRACT:

Background

Genetic ancestry, sex, and individual alleles have been associated with multiple sclerosis (MS) susceptibility.

Objective

To determine whether established risk factors for disease onset are associated with relapse rate in pediatric MS.

Methods

Whole-genome genotyping was performed for 181 MS or high-risk clinically isolated syndrome patients from two pediatric MS centers. Relapses and disease-modifying therapies were recorded as part of continued follow-up. Participants were characterized for 25-hydroxyvitamin D serum status. Ancestral estimates (STRUCTURE v2.3.1), human leukocyte antigen (HLA)-DRB1*15 carrier status (direct sequencing), sex, and a genetic risk score (GRS) of 110 non-HLA susceptibility single-nucleotide polymorphisms (SNPs) were evaluated f

SUBMITTER: Graves JS 

PROVIDER: S-EPMC4945462 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature