Genetics of non-alcoholic fatty liver disease: From susceptibility and nutrient interactions to management.

ABSTRACT: Genetics plays an important role in determining the susceptibility of an individual to develop a disease. Complex, multi factorial diseases of modern day (diabetes, cardiovascular disease, hypertension and obesity) are a result of disparity between the type of food consumed and genes, suggesting that food which does not match the host genes is probably one of the major reasons for developing life style diseases. Non-alcoholic fatty liver is becoming a global epidemic leading to substantial morbidity. While various genotyping approaches such as whole exome sequencing using next generation sequencers and genome wide association studies have identified susceptibility loci for non-alcoholic fatty liver disease (NAFLD) including variants in patatin-like phospholipase domain containing 3 and tra

SUBMITTER: Ravi Kanth VV 

PROVIDER: S-EPMC4945502 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature