Adjustment of lifetime risks of space radiation-induced cancer by the healthy worker effect and cancer misclassification.

ABSTRACT: Background. The healthy worker effect (HWE) is a source of bias in occupational studies of mortality among workers caused by use of comparative disease rates based on public data, which include mortality of unhealthy members of the public who are screened out of the workplace. For the US astronaut corp, the HWE is assumed to be strong due to the rigorous medical selection and surveillance. This investigation focused on the effect of correcting for HWE on projected lifetime risk estimates for radiation-induced cancer mortality and incidence. Methods. We performed radiation-induced cancer risk assessment using Poisson regression of cancer mortality and incidence rates among Hiroshima and Nagasaki atomic bomb survivors. Regression coefficients were used for generating risk coefficients for th

SUBMITTER: Peterson LE 

PROVIDER: S-EPMC4945756 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature