Construction of feasible and accurate kinetic models of metabolism: A Bayesian approach.

ABSTRACT: Kinetic models are essential to quantitatively understand and predict the behaviour of metabolic networks. Detailed and thermodynamically feasible kinetic models of metabolism are inherently difficult to formulate and fit. They have a large number of heterogeneous parameters, are non-linear and have complex interactions. Many powerful fitting strategies are ruled out by the intractability of the likelihood function. Here, we have developed a computational framework capable of fitting feasible and accurate kinetic models using Approximate Bayesian Computation. This framework readily supports advanced modelling features such as model selection and model-based experimental design. We illustrate this approach on the tightly-regulated mammalian methionine cycle. Sampling from the posterior dist

SUBMITTER: Saa PA 

PROVIDER: S-EPMC4945864 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature