Meta-analysis of Telomere Length in Alzheimer's Disease.

ABSTRACT:

Background

Alzheimer's disease (AD) is a common and severe neurodegenerative disorder. Human telomeres are fundamental for the maintenance of genomic stability and play prominent roles in both cellular senescence and organismal aging. Regulation of telomere length (TL) is the result of the complex interplay between environmental and genetic factors. Alterations in TL are increasingly being studied as a possible risk factor for AD, and published studies on TL in AD show discrepant results, highlighting the need for a meta-analysis.

Methods

In the current study, we carried out a meta-analysis of published studies of TL in AD patients and healthy controls. PubMed, Web of Science and Google Scholar databases (from inception to September 2015) were used to identify relevant artic

SUBMITTER: Forero DA 

PROVIDER: S-EPMC4945891 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature