The establishment of the objective diagnostic markers and personalized medical intervention in patients with major depressive disorder: rationale and protocol.

ABSTRACT:

Background

Major depressive disorders (MDD) is a common mental disorder with high prevalence, frequent relapse and associated with heavy disease burden. Heritability, environment and their interaction play important roles in the development of MDD. MDD patients usually display a wide variation in clinical symptoms and signs, while the diagnosis of MDD is relatively subjective. The treatment response varies substantially between different subtypes of MDD patients and only half respond adequately to the first antidepressant. This study aims to define subtypes of MDD, develop multi-dimension diagnostic test and combined predictors for improving the diagnostic accuracy and promoting personalized intervention in MDD patients.

Methods/design

This is a multi-center, multi-stage and

SUBMITTER: Lv X 

PROVIDER: S-EPMC4946102 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature