Admission hyperglycemia and outcome after intravenous thrombolysis: is there a difference among the stroke-subtypes?

ABSTRACT:

Background

The prognostic influence of hyperglycemia in acute stroke has been well established. While in cortical stroke there is a strong association between hyperglycemia and poor outcome, this relation is less clear in lacunar stroke. It has been suggested that this discrepancy is present among patients treated with intravenous tissue plasminogen activator (tPA), but confirmation is needed.

Methods

In two prospectively collected cohorts of patient treated with intravenous tPA for acute ischemic stroke, we investigated the effect of hyperglycemia (serum glucose level >8 mmol/L) on functional outcome in lacunar and non-lacunar stroke. Poor functional outcome was defined as modified Rankin Scale score ≥ 3 at 3 months.

Results

A total of 1012 patients was included of w

SUBMITTER: Miedema I 

PROVIDER: S-EPMC4946238 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature