Serum Concentrations of Selenium and Copper in Patients Diagnosed with Pancreatic Cancer.

ABSTRACT:

Purpose

Understanding of the etiology and pathogenesis of pancreatic cancer (PaCa) is still insufficient. This study evaluated the associations between concentrations of selenium (Se) and copper (Cu) in the serum of PaCa patients.

Materials and methods

The study included 100 PaCa patients and 100 control subjects from the same geographical region in Poland. To determine the average concentration of Se, Cu, and ratio Cu:Se in the Polish population, assay for Se and Cu was performed in 480 healthy individuals. Serum levels of Se and Cu were measured using inductively coupled plasma mass spectrometry.

Results

In the control group, the average Se level was 76 µg/L and Cu 1,098 µg/L. The average Se level among PaCa patients was 60 µg/L and the mean Cu level was 1,432 µg/L.

SUBMITTER: Lener MR 

PROVIDER: S-EPMC4946347 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature