The Overexpression of CCAR1 in Hepatocellular Carcinoma Associates with Poor Prognosis.

ABSTRACT:

Purpose

Cell division cycle and apoptosis regulator 1 (CCAR1) plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, β-catenin, and p53 in a variety of cell types including different cancer cells. However, whether CCAR1 protein is overexpressed in hepatocellular carcinoma (HCC) and the prognostic significance of CCAR1 protein expression in HCC have not been reported.

Materials and methods

In 167 HCC patients with long-term follow-up, CCAR1 protein expression was examined by immunohistochemistry.

Results

High CCAR1 protein expression was observed in 149 of the 167 HCC cases (89.2%) and showed significant correlation with microvascular invasion, intrahepatic metastasis, higher American Joint Committ

SUBMITTER: Ha SY 

PROVIDER: S-EPMC4946359 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature