Patterns of Immune Regulation in Rhesus Macaque and Human Families.

ABSTRACT:

Unlabelled

Naturally acquired immune regulation amongst family members can result in mutual regulation between living related renal transplant donor and recipients. Pretransplant bidirectional regulation predisposed to superior renal allograft outcome in a CAMPATH-1H protocol. We tested whether Rhesus macaques, a large animal model of choice for preclinical transplant studies, share these immunoregulatory properties.

Methods

Antigen-specific linked suppression was measured by trans vivo delayed-type hypersensitivity [tvDTH] response. Neutralizing antibodies to regulatory cytokines, IL-10, TGF-β, and IL-35 were coinjected to ascertain the role of these cytokines in the regulatory response.

Results

Peripheral blood mononuclear cells (PBMC) of 116 Rhesus macaques in 50 f

SUBMITTER: Burlingham WJ 

PROVIDER: S-EPMC4946471 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature