Ontology highlight
ABSTRACT:
SUBMITTER: Petersen KF
PROVIDER: S-EPMC4946568 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Cell metabolism 20160701 1
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and there is great interest in understanding the potential role of alterations in mitochondrial metabolism in its pathogenesis. To address this question, we assessed rates of hepatic mitochondrial oxidation in subjects with and without NAFLD by monitoring the rate of (13)C labeling in hepatic [5-(13)C]glutamate and [1-(13)C]glutamate by (13)C MRS during an infusion of [1-(13)C]acetate. We found that rates of hepa ...[more]