Human MAIT-cell responses to Escherichia coli: activation, cytokine production, proliferation, and cytotoxicity.

ABSTRACT: Mucosa-associated invariant T cells are a large and relatively recently described innate-like antimicrobial T-cell subset in humans. These cells recognize riboflavin metabolites from a range of microbes presented by evolutionarily conserved major histocompatibility complex, class I-related molecules. Given the innate-like characteristics of mucosa-associated invariant T cells and the novel type of antigens they recognize, new methodology must be developed and existing methods refined to allow comprehensive studies of their role in human immune defense against microbial infection. In this study, we established protocols to examine a range of mucosa-associated invariant T-cell functions as they respond to antigen produced by Escherichia coli These improved and dose- and time-optimized experi

SUBMITTER: Dias J 

PROVIDER: S-EPMC4946616 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature