Type 1 diabetes genetic susceptibility and dendritic cell function: potential targets for treatment.

ABSTRACT: Type 1 diabetes is an autoimmune disease that results from the defective induction or maintenance of T cell tolerance against islet β cell self-antigens. Under steady-state conditions, dendritic cells with tolerogenic properties are critical for peripheral immune tolerance. Tolerogenic dendritic cells can induce T cell anergy and deletion and, in some contexts, induce or expand regulatory T cells. Dendritic cells contribute to both immunomodulatory effects and triggering of pathogenesis in type 1 diabetes. This immune equilibrium is affected by both genetic and environmental factors that contribute to the development of type 1 diabetes. Genome-wide association studies and disease association studies have identified >50 polymorphic loci that lend susceptibility or resistance to insulin-depe

SUBMITTER: Hotta-Iwamura C 

PROVIDER: S-EPMC4946618 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature