Molecular profiling reveals primary mesothelioma cell lines recapitulate human disease.

ABSTRACT: Malignant mesothelioma (MM) is an aggressive, fatal tumor strongly associated with asbestos exposure. There is an urgent need to improve MM patient outcomes and this requires functionally validated pre-clinical models. Mesothelioma-derived cell lines provide an essential and relatively robust tool and remain among the most widely used systems for candidate drug evaluation. Although a number of cell lines are commercially available, a detailed comparison of these commercial lines with freshly derived primary tumor cells to validate their suitability as pre-clinical models is lacking. To address this, patient-derived primary mesothelioma cell lines were established and characterized using complementary multidisciplinary approaches and bioinformatic analysis. Clinical markers of mesothelioma,

SUBMITTER: Chernova T 

PROVIDER: S-EPMC4946883 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature