Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation.

ABSTRACT: Bacterial spores are the most resistant form of life known on Earth and represent a serious problem for (i) bioterrorism attack, (ii) horizontal transmission of microbial pathogens in the community, and (iii) persistence in patients and in a nosocomial environment. Stage II sporulation protein D (SpoIID) is a lytic transglycosylase (LT) essential for sporulation. The LT superfamily is a potential drug target because it is active in essential bacterial processes involving the peptidoglycan, which is unique to bacteria. However, the absence of structural information for the sporulation-specific LT enzymes has hindered mechanistic understanding of SpoIID. Here, we report the first crystal structures with and without ligands of the SpoIID family from two community relevant spore-forming pathog

SUBMITTER: Nocadello S 

PROVIDER: S-EPMC4946911 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature