Immune-mediated reactions to vancomycin: A systematic case review and analysis.

ABSTRACT:

Background

Vancomycin is a broad-spectrum antibiotic whose use may be limited by adverse drug reactions (ADRs). Although vancomycin toxic effects are known, there are limited data on vancomycin hypersensitivity reactions (HSRs).

Objective

To understand the most commonly reported vancomycin HSRs through systematic case review.

Methods

We performed a literature search for English-language case reports and series from 1982 through 2015 (last search July 31, 2015) on Ovid MEDLINE and PubMed. The search included the subject heading vancomycin with the subheading adverse effects and separate text searches for vancomycin with a list of specified HSRs. References of identified articles were reviewed to find additional articles. Clinical data were collected and summarized.

SUBMITTER: Minhas JS 

PROVIDER: S-EPMC4946960 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature