Brain mechanisms of anxiety's effects on cognitive control in major depressive disorder.

ABSTRACT:

Background

Adults with major depressive disorder (MDD) demonstrate increased susceptibility to interfering effects of anxiety on cognitive control; although under certain conditions adults with MDD are able to compensate for these effects. The brain mechanisms that may facilitate the ability to compensate for anxiety either via the recruitment of additional cognitive resources or via the regulation of interference from anxiety remain largely unknown. To clarify these mechanisms, we examined the effects of anxiety on brain activity and amygdala-prefrontal functional connectivity in adults diagnosed with MDD.

Method

A total of 22 unmedicated adults with MDD and 18 healthy controls (HCs) performed the Tower of London task under conditions designed to induce anxiety, while under

SUBMITTER: Jones NP 

PROVIDER: S-EPMC4946974 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature