Applying amide proton transfer-weighted MRI to distinguish pseudoprogression from true progression in malignant gliomas.

ABSTRACT:

Purpose

To assess amide proton transfer-weighted (APTW) imaging features in patients with malignant gliomas after chemoradiation and the diagnostic performance of APT imaging for distinguishing true progression from pseudoprogression.

Materials and methods

After approval by the Institutional Review Board, 32 patients with clinically suspected tumor progression in the first 3 months after chemoradiation were enrolled and scanned at 3T. Longitudinal routine magnetic resonance imaging (MRI) changes and medical records were assessed to confirm true progression versus pseudoprogression. True progression was defined as lesions progressing on serial imaging over 6 months, and pseudoprogression was defined as lesions stabilizing or regressing without intervention. The APTWmean and A

SUBMITTER: Ma B 

PROVIDER: S-EPMC4946988 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature