Selectivity of stimulus induced responses in cultured hippocampal networks on microelectrode arrays.

ABSTRACT: Sensory information can be encoded using the average firing rate and spike occurrence times in neuronal network responses to external stimuli. Decoding or retrieving stimulus characteristics from the response pattern generally implies that the corresponding neural network has a selective response to various input signals. The role of various spiking activity characteristics (e.g., spike rate and precise spike timing) for basic information processing was widely investigated on the level of neural populations but gave inconsistent evidence for particular mechanisms. Multisite electrophysiology of cultured neural networks grown on microelectrode arrays is a recently developed tool and currently an active research area. In this study, we analyzed the stimulus responses represented by network-w

SUBMITTER: Pimashkin A 

PROVIDER: S-EPMC4947052 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature