RNA polymerase I-Rrn3 complex at 4.8 A resolution.

ABSTRACT: Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 Å resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation.

SUBMITTER: Engel C 

PROVIDER: S-EPMC4947163 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature