Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test.

ABSTRACT:

Background

Inhaled allergen challenge is a validated disease model of allergic asthma offering useful pharmacodynamic assessment of pharmacotherapeutic effects in a limited number of subjects.

Objectives

To evaluate whether an RNA signature can be identified from induced sputum following an inhaled allergen challenge, whether a RNA signature could be modulated by limited doses of inhaled fluticasone, and whether these gene expression profiles would correlate with the clinical endpoints measured in this study.

Methods

Thirteen non-smoking, allergic subjects with mild-to-moderate asthma participated in a randomised, placebo-controlled, 2-period cross-over study following a single-blind placebo run-in period. Each period consisted of three consecutive days, separated by

SUBMITTER: Zuiker RG 

PROVIDER: S-EPMC4947196 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature