Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.

ABSTRACT: Genome-wide association studies (GWAS) have traditionally been undertaken in homogeneous populations from the same ancestry group. However, with the increasing availability of GWAS in large-scale multi-ethnic cohorts, we have evaluated a framework for detecting association of genetic variants with complex traits, allowing for population structure, and developed a powerful test of heterogeneity in allelic effects between ancestry groups. We have applied the methodology to identify and characterise loci associated with susceptibility to type 2 diabetes (T2D) using GWAS data from the Resource for Genetic Epidemiology on Adult Health and Aging, a large multi-ethnic population-based cohort, created for investigating the genetic and environmental basis of age-related diseases. We identified a no

SUBMITTER: Cook JP 

PROVIDER: S-EPMC4947384 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature