Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract.

ABSTRACT: Inflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important components of complex physiological processes and many local and systemic pathologies. It is well established that intracoital and postcoital function of seminal fluid (SF) goes beyond nutritive support for the spermatozoa cells. SF, in particular, the inflammatory bioactive lipids, and prostaglandins present in vast quantities in SF, have a role in localized immune modulation and regulation of pathways that can exacerbate inflammation in the FMRT. In sexually active women SF-mediated inflammation has

SUBMITTER: Adefuye AO 

PROVIDER: S-EPMC4947502 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature