Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

ABSTRACT:

Background

Histologic chorioamnionitis (HCA) is commonly associated with preterm birth and deleterious post-natal outcomes including sepsis and necrotizing enterocolitis. Transcriptomic analysis has been used to uncover gene signatures that permit diagnosis and prognostication, show new therapeutic targets, and reveal mechanisms that underlie differential outcomes with other complex disease states in neonates such as sepsis.

Aims

To define the transcriptomic and inflammatory protein response in peripheral blood among infants with exposure to histologic chorioamnionitis.

Study design

Prospective, observational study.

Subjects

Uninfected preterm neonates retrospectively categorized based on placental pathology with no HCA exposure (n=18) or HCA exposure (n=15).

SUBMITTER: Weitkamp JH 

PROVIDER: S-EPMC4947555 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature