Overexpression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and poor overall survival.

ABSTRACT:

Background

Copy-number gain of the oncostatin-M receptor (OSMR) occurs frequently in cervical squamous cell carcinoma (SCC) and is associated with adverse clinical outcome. We previously showed that OSMR overexpression renders cervical SCC cells more sensitive to the major ligand oncostatin-M (OSM), which increases migration and invasion in vitro. We hypothesised that a major contribution to this phenotype would come from epithelial-mesenchymal transition (EMT).

Methods

We performed a comprehensive integrated study, involving in vitro cell line studies, in vivo animal models and numerous clinical samples from a variety of anatomical sites.

Results

In independent sets of cervical, head/neck and lung SCC tissues, OSMR expression levels correlated with multiple EMT-assoc

SUBMITTER: Kucia-Tran JA 

PROVIDER: S-EPMC4947707 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature