The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.

ABSTRACT:

Aim

Coinfecting bacterial pathogens are a major cause of morbidity and mortality in influenza. However, there remains a paucity of literature on the magnitude of coinfection in influenza patients.

Method

A systematic search of MeSH, Cochrane Library, Web of Science, SCOPUS, EMBASE, and PubMed was performed. Studies of humans in which all individuals had laboratory confirmed influenza, and all individuals were tested for an array of common bacterial species, met inclusion criteria.

Results

Twenty-seven studies including 3215 participants met all inclusion criteria. Common etiologies were defined from a subset of eight articles. There was high heterogeneity in the results (I(2)  = 95%), with reported coinfection rates ranging from 2% to 65%. Although only a subset of pa

SUBMITTER: Klein EY 

PROVIDER: S-EPMC4947938 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature