Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study.

ABSTRACT:

Objective

 To determine the association between use of sulphonylureas and risk of hypoglycaemia in relation to renal function and sulphonylurea metabolic group compared with use of metformin.

Design

 Population based cohort study using routinely collected data from general practices in England.

Setting

 Clinical Practice Research Datalink (CPRD) database, 2004-12.

Participants

 120 803 new users of a non-insulin antidiabetic agent with at least one prescription and aged 18 years or more. The first prescription defined start of follow-up. Patients were followed until the end of data collection, a record for hypoglycaemia, or a blood glucose level of less than 3.0 mmol/L.

Main outcome measures

 Associations between sulphonylurea dose, renal impairment, typ

SUBMITTER: van Dalem J 

PROVIDER: S-EPMC4948031 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature