Diabetes treatments and risk of heart failure, cardiovascular disease, and all cause mortality: cohort study in primary care.

ABSTRACT:

Objective

 To assess associations between risks of cardiovascular disease, heart failure, and all cause mortality and different diabetes drugs in people with type 2 diabetes, particularly newer agents, including gliptins and thiazolidinediones (glitazones).

Design

 Open cohort study.

Setting

 1243 general practices contributing data to the QResearch database in England.

Participants

 469 688 people with type 2 diabetes aged 25-84 years between 1 April 2007 and 31 January 2015.

Exposures

 Diabetes drugs (glitazones, gliptins, metformin, sulphonylureas, insulin, other) alone and in combination.

Main outcome measure

 First recorded diagnoses of cardiovascular disease, heart failure, and all cause mortality recorded on the patients' primary care, mort

SUBMITTER: Hippisley-Cox J 

PROVIDER: S-EPMC4948032 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature