Zeta Sperm Selection Improves Pregnancy Rate and Alters Sex Ratio in Male Factor Infertility Patients: A Double-Blind, Randomized Clinical Trial.

ABSTRACT:

Background

Selection of sperm for intra-cytoplasmic sperm injection (ICSI) is usually considered as the ultimate technique to alleviate male-factor infertility. In routine ICSI, selection is based on morphology and viability which does not necessarily preclude the chance injection of DNA-damaged or apoptotic sperm into the oocyte. Sperm with high negative surface electrical charge, named "Zeta potential", are mature and more likely to have intact chromatin. In addition, X-bearing spermatozoa carry more negative charge. Therefore, we aimed to compare the clinical outcomes of Zeta procedure with routine sperm selection in infertile men candidate for ICSI.

Materials and methods

From a total of 203 ICSI cycles studied, 101 cycles were allocated to density gradient centrifugation

SUBMITTER: Nasr Esfahani MH 

PROVIDER: S-EPMC4948079 | biostudies-literature | 2016 Jul-Sep

REPOSITORIES: biostudies-literature