Nonsynonymous HTR2C polymorphism predicts cortisol response to psychosocial stress I: Effects in males and females.

ABSTRACT:

Background

Genetic influences on stress reactivity may provide insight into depression risk mechanisms. The C-allele of rs6318, a putatively functional polymorphism located within the HTR2C gene, has been reported to predict greater cortisol and negative affective reactivity to lab-induced stress. However, the potential moderating effect of sex has not been examined despite X-linkage of HTR2C. We hypothesized that sex moderates the effect of rs6318 on cortisol and affective reactivity to lab-induced stress, with males showing stronger effects.

Methods

Non-depressed young adults (N=112; 39 female) screened via clinical interview provided a DNA sample and completed either a negative evaluative Trier Social Stress Test, or a non-evaluative control protocol. Salivary cortisol an

SUBMITTER: Avery BM 

PROVIDER: S-EPMC4948185 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature