Heme Oxygenase-1 in Kidney Health and Disease.

ABSTRACT:

Significance

Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a considerable burden in healthcare. The heme oxygenase (HO) system plays an important role in regulating oxidative stress and is protective in a variety of human and animal models of kidney disease. Preclinical studies of the HO system have led to the development of several clinical trials targeting the enzyme or its products.

Recent advances

Connection of HO, ferritin, and other proteins involved in iron regulation has provided important insight into mechanisms of damage in AKI. Also, HO-1 expression is important in the pathogenesis of hypertension, diabetic kidney disease, and progression to end-stage renal disease.

Critical issues

Despite intriguing discoveries, no drugs targeting th

SUBMITTER: Lever JM 

PROVIDER: S-EPMC4948210 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature