Exploring the role of molecular biomarkers as a potential weapon against gastric cancer: A review of the literature.

ABSTRACT: Gastric cancer (GC) is a global health problem and a major cause of cancer-related death with high recurrence rates ranging from 25% to 40% for GC patients staging II-IV. Unfortunately, while the majority of GC patients usually present with advanced tumor stage; there is still limited evidence-based therapeutic options. Current approach to GC management consists mainly of; endoscopy followed by, gastrectomy and chemotherapy or chemo-radiotherapy. Recent studies in GC have confirmed that it is a heterogeneous disease. Many molecular characterization studies have been performed in GC. Recent discoveries of the molecular pathways underlying the disease have opened the door to more personalized treatment and better predictable outcome. The identification of molecular markers is a useful tool f

SUBMITTER: Matboli M 

PROVIDER: S-EPMC4948264 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature