Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization.

ABSTRACT: Recent advancements in material science and engineering may hold the key to overcoming reproducibility and scalability limitations currently hindering the clinical translation of stem cell therapies. Biomaterial assisted differentiation commitment of stem cells and modulation of their in vivo function could have significant impact in stem cell-centred regenerative medicine approaches and next gen technological platforms. Synthetic biomaterials are of particular interest as they provide a consistent, chemically defined, and tunable way of mimicking the physical and chemical properties of the natural tissue or cell environment. Combining emerging biomaterial and biofabrication advancements may finally give researchers the tools to modulate spatiotemporal complexity and engineer more h

SUBMITTER: Seale NM 

PROVIDER: S-EPMC4948647 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature