Polychlorinated biphenyl exposure alters the expression profile of microRNAs associated with vascular diseases.

ABSTRACT: Exposure to persistent organic pollutants, including polychlorinated biphenyls (PCBs) is correlated with multiple vascular complications including endothelial cell dysfunction and atherosclerosis. PCB-induced activation of the vasculature subsequently leads to oxidative stress and induction of pro-inflammatory cytokines and adhesion proteins. Gene expression of these cytokines/proteins is known to be regulated by small, endogenous oligonucleotides known as microRNAs that interact with messenger RNA. MicroRNAs are an acknowledged component of the epigenome, but the role of environmentally-driven epigenetic changes such as toxicant-induced changes in microRNA profiles is currently understudied. The objective of this study was to determine the effects of PCB exposure on microRNA expression pr

SUBMITTER: Wahlang B 

PROVIDER: S-EPMC4949395 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature